Mandy´s Story – Primary Progressive Multiple Sclerosis

Mandy is 28 years old and four years ago she was an Ironwoman. She could climb mountains, ride her bike for many hours and swim many miles. All of the sudden she noticed a rapid deterioration of her physical condition.

She was diagnosed with Multiple Sclerosis (MS), particularity Primary Progressive Multiple Sclerosis due to her rapid deterioration with no relapse. In short, MS affects a vital tissue that surrounds the nerves called myelin, the effects of which appear as symptoms over the entire body.

Mandy showed a marked difficulty in her gait, stability, bladder control and bowel movements. On top of that, her mood was remarkably affected.

Our recommendation was that she make a map of the stool bacteria ( and so she did. This study showed that she had a pattern of bacteria distribution similar to the one the patients with inflammatory bowel diseases have. The results are shown below:

The Cyrex report shows that Mandy is sensitive to 56% of all the analyzed food (Pink Column “Out of Range”).

Based on this finding, we decided to start treating her condition with Fecal Microbiota Transplant (FMT).Mandy underwent a series of 20 consecutive fecal transplants in August 2015, then she took frozen specimens to continue with the transplants at home.

Right after starting with the treatment Mandy notice some improvement in her bladder control, and slowly thereafter her bowel movements started to become more regular. She could also sleep all night without having to urinate.. Now, four months after starting the treatment, she reports normal bowel movements, that her neurological symptoms seem to be better stabilized , and she has seen no deterioration of her condition since starting FMT. The most noticeable change seems to be her mood.. She feels less depressed and despaired, optimism has emerged as something new in her life.

One of the most powerful indicators that we have found in her positive evolution is her change in the Cyrex panel. Below is the food sensitivity test after FMT showing that she is no longer sensitive to various foods.

In the “Out of range” column there are no foods marked as sensitive.

Bottom line, Mandy has not suffered further neurological deterioration since her FMT treatment and there is a possibility that the future deterioration can strongly influenced by modifying her microbiota. For the moment, MS and especially the aggressive form that Mandy has, has no treatment. Fecal Microbiota Transplant is a harmless therapy with only potential minor side effects that has shown significant potential to restore one of the key players in the inflammatory diseases: bacteria.